Síntese de (Z)-Tioeninos e Tiofenos Utilizando PEG-400 e Irradiação de Micro-ondas

Abstract

In this work, we developed a method to synthesize (Z)-thioenynes 3a-f from symmetrical 1,3-diacetylenes 1a-c and diaryl disulfides 2a-d using sodium borohydride and PEG-400. This easy, general and simple method provides the corresponding vinyl sulfides preferentially with Z configuration, under reaction conditions of 60 °C using microwave irradiation and conventional heating. When the same reaction was carried out at 90 °C, it was possible to obtain the corresponding thiophenes 4a-d in good yields.