Síntese de 1-H-1,5-Benzodiazepinas Utilizando Metodologias Verdes

Abstract

In this work we studied the condensation between ketones and aromatic diamines to obtain the 1-H-1,5-Benzodiazepines. We developed a new synthetic methodology, clean and efficient using SiO2/ZnCl2 (30%) and solvent-free. These reactions were performed at room temperature and under microwave irradiation (Scheme 1). When microwave irradiation was used the reaction was facilitated by decreasing the reaction time and the catalytic system was reused up to four times. On the other hand, another methodology was developed using glycerol as a clean solvent and without catalytic system (Scheme 2). The reaction was performed at 90 °C and glycerol was reused in four reactions. The procedures for the synthesis of 1-H-1,5-Benzodiazepines were obtained in good yields.