Preditores de doenças e desempenho zootécnico em bezerras leiteiras

Abstract

Neonatal calves diarrhea and bronchopneumonia are diseases that cause great losses. The early diagnostic of these diseases becomes crucial to establish a fast and suitable therapeutic protocol.The objective of this study was to determine the metabolic and immune response of neonatal cattle affected with enteric and respiratory infections, as well as determining possible markers for early diagnosis and monitoring. For this study36 Holsteins calveswere monitored from birth until 42 days of life. Liver biopsies were performedat birth and regular blood collections until the diagnosis of bronchopneumonia or neonatal diarrhea, as well as weekly measurements of growth performance. During the study, 6 calves kept healthy, 12 had bronchopneumonia and 18 had diarrhea. In the previous period of clinical symptoms, serum concentrations of TGG, TPP, albumin, paraoxanase and haptoglobin were measured to identify predictive markers of the occurrence of neonatal diseases. At birth, the hepatic expression of GHR1A, IGF1, STAT3, NFKB1 and SOD2 were evaluated.After the diagnosis of diarrhea the calves were submitted to different treatments and evaluate their clinical response. The paraoxonase see med to be an important predictive marker of neonatal diseases, as it was altered even before the clinical signal of the diseases. Regarding the treatment used in diarrhea diseases, antibiotic use associated with orallyenergy and electrolytic replacement showed the best results in terms of metabolic profile and inflammatory condition on the neonate.