Novos compostos organosselênio bioativos: estudo da ação antimicrobiana frente à patógenos de importância em alimentos

Abstract

Java citronella (Cymbopogon nardus (L) Rendle) belongs to the genus Cymbopogon and the essential oil extracted from the plant is constituted mainly by the (+)-R-citronellal (3,7-dimethyl-6-octenal), formed by the secondary metabolism plants. Essential oils and plant extracts have a growing interest to industry and scientific research due to its antimicrobial activity, and as well as compounds organosselênios that are of great interest for scientific research because of its wide spectrum of biological activity. Thus, we performed a study of α-selenation of aldehydes and ketones, including the (+)-( R)-citronellal, as a major component of essential oil of citronella, using PEG/KF/Al2O3, as a recyclable medium. Derivatives of (+)- (R)-citronellal containing organoselenium were assessed for their potential antimicrobial, the antimicrobial activity was determined by the techniques of disk diffusion and minimum inhibitory concentration. The 2-phenylseleno citronellal and 2 phenylseleno citronellol provided yields of 71 and 73% respectively. The antimicrobial activity of 2- phenylseleno citronellal showed the best results, soon the addition of a organoselenium to (+)-R-citronellal increased the antimicrobial activity of (+)-R-citronellal against foodborne pathogenic bacteria Listeria monocytogenes, Staphylococcus aureus and Salmonella Typhimurium.