Efeito da suplementação com extrato de Pleurotus albidus na resistência insulínica

Abstract

Insulin resistance consists of a decrease in the cellular and tissue response to physiological concentrations of the hormone insulin. It has been shown that mushrooms can attenuate the occurrence of hyperglycemia and insulin resistance. Among a wide variety of mushrooms, those of the genus Pleurotus have several medicinal properties, Pleurotus albidus, the target of this study, is a species that stands out for having been little studied and for having great anti-hyperglycemic potential. The aim of the present study is to determine whether supplementation with Pleurotus albidus extract attenuates insulin resistance. Five experimental groups were used, the control received saline solution and the others received dexamethasone. This was administered alone or with the addition of treatment and/or supplementation of metformin, Pleurotus ostreatus and Pleurotus albidus. Glucose and insulin tolerance tests were used, which showed that the treatment using P. albidus extract showed the ability to prevent insulin resistance in C57BL/6 mice treated for forty days. These data showed a tendency to attenuate blood glucose, in a more favorable way than the drug metformin. In this context, it is noteworthy that Pleurotus albidus has the potential to add benefits to human health, essentially due to its antioxidant and hypoglycemic effects.