Sistema de liberação de fármaco a base de membranas de celulose nanocristalina

Abstract

Cellulose is an abundant natural polymer and materials from renewable sources has motivated a number of studies because it is eco-friendly. On the other hand, the drug release technology represents one of the boundaries of science, involving different multidisciplinary aspects and contributing to the advancement of human health. This work aimed the development of a drug release system based on nanocrystalline cellulose (CNC), derived from a renewable resource. For this, the nanocelulose was obtained from flax and characterized by different techniques, such as: X-Ray Diffraction, Atomic Force Microscopy, Zeta Potential, Fourier Transform Infrared Spectroscopy (FT-IR), Magnetic Resonance Nuclear, among others. Subsequently, through the insertion of drug chlorhexidine into the suspension of cellulose nanocrystals a membrane was formed. The obtained membranes were characterized by Infrared Spectroscopy with Fourier Transform (FT-IR), Nuclear Magnetic Resonance, Scanning Electron Microscopy and Atomic Force Microscopy. The evaluation of the rate of drug release was performed using the Ultraviolet–visible spectroscopy technique. Antibacterial activity (S. aureus) and cytotoxicity (L929 fibroblasts) were evaluated and the results demonstrated that cellulose nanocrystals membranes are efficient drug delivery systems.