Síntese de Tiazolidinonas e Tiazinanonas Derivados de 4-(aminoalquil) Morfolinas.

Abstract

An efficient multicomponent reaction of arenealdehydes, mercaptoacetic acid and 2-morpholinoethylamine and 3-morpholinopropylamine by conventional and sonochemistry methodologies to afford the corresponding 2-aryl-3-(morpholinoethyl)-1,3-thiazolidin-4-ones and 2-aryl-3-(morpholinopropyl)-1,3-thiazolidin-4-ones was described. Furthemore, were synthetised thiazolidinones from pyridin-2-amine, pyrimidin-2-amine, benzo[d][1,3]dioxol-5-ylmetanamine, pyridine-3-ylmethanamine and 2-amnioethylmorpholine. The purity of the products were confirmed by analysis from gas chromatography. In this work were also synthesized thiazinanones from 2-aminoethylmorfoline by convetional and sonochemistry methodologies. Were synthesized 48 compounds unpublished in the literature and these compounds were confirmed and characterized by 1H and 13C NMR, mass and some these were confirmed by high resolution mass and elemental analyses.