Associação entre nível de atividade física e parâmetros de saúde em pacientes com doença renal crônica submetidos a hemodiálise

Abstract

Objective:This study aimed to verify the association between physical activity level, strength, functional capacity, muscle thickness and quality and inflammatory and oxidative stress parameters in hemodialysis patients.Materials and methods:This wasa cross-sectional observational study using data previously collected in a randomized controlled trial. To be included in the study, individuals with chronic kidney diseaseshould hadhemodialysisat the nephrology reference unit of the São Francisco de Paula hospital and 18 years of age or older. The data were entered into an Excel spreadsheet and weredouble-checked to avoid errors, and the bank was later transferred to Stata statistical software.Results and discussion:The present study, after adjusted analysis, among all initial possibilities, showed an inverse association only between the variablesmuscle thickness and stress oxidative parameter TBARS. The lack of statistically significant association amongother exposures couldbe explained as a result of the great physical weakness in which individuals were, since the process of hemodialysis is known to lead to great loss of muscle mass, altering metabolic routes of protein synthesis. Conclusion:The present study found an inverse association between muscle thickness and the oxidative stress marker TBARS.The lack of association amongother exposures and outcomes suggesteda picture of evident loss of functional capacity and decreased level of physical activity and strength, probably caused by chronic kidney disease and hemodialysis treatment in individuals. Interventions to improve physical fitness, physical activity levels and muscle variables appear to be essential for chronic renal failure patients on hemodialysis.