Efeitos crônicos de diferentes modelos de exercício físico sobre parâmetros comportamentais e do sistema colinérgico em um modelo experimental de neuroinflamação.

Abstract

Objective: To compare the effects of six weeks of high intensity intermittent exercise and continuous moderate exercise on locomotor activity, memory and activity of the AChE and Na+K+-ATPase enzymes of female C57BL/6 mice induced by lipopolysaccharide neuroinflammation (LPS). Methods: The animals were divided into three groups: control group (CG) (n = 10), continuous intensity group (GCON) (n = 10) and high intensity intermittent exercise group (n = 10) . Seventy-two hours after the last exercise session, animals received an injection with 250 μg/kg of LPS from Escherichia coli bacteria. Results: Physical exercise protocols did not modify any of the parameters evaluated by the open field test. The HIIT group presented higher percentage of object exploration in the object recognition memory test compared to the GCON group [F (2,25) = 5.01, p = 0.01]. The HIIT group showed higher activity of the AChE enzyme and reduced Na+K+-ATPase enzyme activity in the cerebral cortex, and GCON showed higher Na+K+-ATPase enzyme activity in the hippocampus. Conclusion: Six weeks of high-intensity intermittent and continuous moderate exercise led to improvements in the short-term memory of the animals, observed through the object recognition memory test, with more significant results in the HIIT group compared to the other groups. After training, elevations in AChE activity and reductions in Na+K+-ATPase were observed in the cerebral cortex of animals that underwent HIIT. Further studies are needed to verify which neurochemical mechanisms are related to physical exercise and how they interfere with the behavior pattern and the memory of the animals.