Adição de tióis a compostos carbonílicos α,β-insaturados utilizando KF/alumina em meio livre de solventeAdição de tióis a compostos carbonílicos α,β-insaturados utilizando KF/alumina em meio livre de solvente

Abstract

In this work, a new methodology for the synthesis of 3-thioorganylcitronellals and others 3-tiosubstituted carbonyl compounds was developed. The method consists in the 1,4-addition of thiols to electron deficient alkenes: such as α,β-unsatured aldehydes, esters, acids and nitriles, using KF/alumina and solvent-free conditions. The 3-thioorganylcitronellals were tested for antimicrobial activity and they showed high activity against Staphylococcus sp.