Síntese de análogos da curcumina e avaliação in vitro da sua atividade antitumoral em câncer de bexiga

Abstract

Bladder cancer is one of the leading causes of cancer-related death in the world. Curcumin, a spice found in curry powder, is receiving considerable attention as a possible chemopreventative and chemotherapeutic. This work was performed to synthesize five curcumin derivatives, from five different aromatic aldehydes, as well as evaluate their cytotoxic potential against human bladder cancer 5637 and non cancer cell line CHO-K1. The compounds were obtained in yields ranging between 50 % and 90 % and analyzed by Gas Chromatography coupled to Mass Spectrometry (CG-MS). Compound 5 displayed the highest cytotoxic activity of all the compounds tested against the 5637 cells, inhibiting 50% of the cells growth after 24h of exposure at a concentration of 9,5µM. In addition, compounds 2, 3 and 4 demonstrated good activities against bladder cancer cell line, inhibiting more than 50% of the cells growth after 24h of exposure. Our results also showed that the synthetized compounds have low cytotoxic effect against cell line CHO-K1.