Avaliação in vitro das atividades antimicrobianas de 2-aril-3-(benzo[d][1,3]dioxol-5-IL) tiazolidin-4-onas

Abstract

This study evaluated the biological properties of twelve 1,3-thiazolidin-4-ones derivated from 3,4-(methylenedioxy)aniline, assessing the antifungal and antibactertial activity of these compounds. The antibacterial assay against Staphylococcus aureus ATCC 19095 and Escherichia coli ATCC 29214 showed that these compounds have no significant effect to inhibit the bacterial growth. The compound 1b showed the best antifungal results against C. albicans ATCC 62342 at 100 µg/ml (61.23% inhibition in 24h and 53.75% in 48h), including demonstrating statistical difference from growth control at lowest concentration used, 25 µg/ml. Thus, the compound 1h was the greatest percentage of growth inhibition against C. parapsilosis at 100 µg/ml (84.73% in 24h and 41.06% in 48h), including being similar to fluconazole in 24h (85.72%). Besides, 1h demonstrated activity since the lowest concentration tested, 25 µg/ml. In antifungal Rhodotorula assay, it was verify two compounds with good antifungal activity at 100 µg/ml in 48h, 1f (82.65% of inhibition) and 1i (68.22%). It is also important to note that both compounds were statistically similar to fluconazole (89.30%). However, analyzing different concentrations, only the compound 1f presented statistical difference from control group. These studies discover at least three potential antifungal agents for three different strains with significant results at low concentrations. Therefore, it is understood that the results create perspectives for further research in order to increase the therapeutic possibilities to fight microbial resistance and diseases caused by microorganisms, and it is emphasized the development of synthesis of 4-thiazolidinones and subsequent evaluation of the pharmacological activity.