1H-Pirazol-1-il-4-feniltiazóis: Reveladores de Impressões Digitais Latentes com Baixa Citotoxicidade

Abstract

Latent fingermark (LFM) when detected at crime scenes are considered as circumstantial evidence in forensic investigations and criminal justice. Such importance is due to the uniqueness in crest pattern for each individual and thus are unique and vital for the identification or involvement of a suspect. For the visualization of an LFM it is necessary that some substance is able to react chemically or physically with the compounds present therein. In view of this, different 1H-pyrazol-1-yl-4-phenylthiazole analogues were synthesized and evaluated for their LFM developer potential, since the compounds show staining and fluorescence. The products were synthesized from thiocarbamoyl pyrazoles and 4-bromoacetophenone in yields of 70-77%. LFM were deposited to evaluate eccrine and sebaceous compounds and developed with the compounds prepared. Scanning electron microscopy (SEM) showed that the compounds in powder form exhibited adhesion compared to commercially bound reagents. In addition, the fluorescence assessment showed high emission in the range of 472-475 nm. The 1H-pyrazol-1-yl-4-phenylthiazole were evaluated for cytotoxicity in keratinocyte cells, presenting positive results with high cell viability. These compounds represent an alternate class of LFM detection reagents. The present study suggests a new application for 1H-pyrazol-1-yl-4-phenylthiazole derivatives as a potential novel latent fingermarking product.