Avaliação do efeito hipolipêmico e anti-inflamatório do extrato de butiá (Butia odorata) em ratos tratados com tyloxapol

Abstract

Hyperlipidemia is one of the metabolic conditions that determine the onset of chronic degenerative diseases, such as atherosclerosis. The formation of the initial lesions seems to be closely linked to the focal increase of the low density lipoprotein (LDL) content within regions of the intima, due not only to changes in the permeability of the overlying endothelium, but mainly because they bind to constituents of the cell matrix, increasing the durability of the lipid-rich particles inside the arterial wall. Therefore, the aim of this study was to investigate the effect of Butia odorata fruit extract on metabolic, inflammatory and oxidative stress parameters in rats submitted to an experimental model of hyperlipidemia induced by tyloxapol. Animals were divided into 3 experimental groups: (1) saline, (2) saline and tyloxapol and (3) B. odorata hydro-alcoholic extract and tyloxapol. The animals were treated for 15 days with saline or extract (200 mg/kg by gavage) and hyperlipidemia was induced by intraperitoneal administration of tyloxapol (300 mg/kg) on day 15. Serum and liver were used for biochemical analyses. Our results showed that B. odorata extract treatment reduced triglyceride levels and total cholesterol, and increased HDL-cholesterol, when compared with tyloxapol group. PON-1 activity (HDL-cholesterol related) increased in serum of animals that received B. odorata extract compared with tyloxapol-treated animals. On other hand, serum C- reactive protein levels, as well as adenosine deaminase and butyrylcholinesterase activities had a significant reduction due to extract treatment. No differences were observed in hepatic oxidative stress parameters. Phenolic compounds were identified and quantified by LC-MS. Our findings suggest that chronic consumption of B. odorata extract has hypolipidemic and anti-inflammatory effects in a hyperlipidemia animal model.