Síntese de selenoésteres a partir de cloretos de acila ou anidridos utilizando PEG-400 como solvente

Abstract

In this study, a green method was described for the synthesis of selenoesters 3, by reacting acyl chlorides 2 and arilselenol generated in situ from reductive cleavage of Se-Se bond different diaryl diselenide 1 with hypophosphorous acid. The reactions were carried out using polyethylene glycol-400 (PEG-400) as solvent, at room temperature and under nitrogen atmosphere. The products were obtained in yields ranging from good to excellent and PEG-400 can be easily recovered and reused. Along the same line of research has described the synthesis of derivatives of glycerol selenoesters 6, using the bis-(2,2-dimethyl-1,3-dioxolanylmethyl)diselenide 4 reacting with different anhydrides 5 using PEG-400 as solvent in the presence of potassium carbonate and Rongalite® for cleavage of Se-Se bond. The products were obtained in yields ranging from moderate to excellent.